• The following are the supplementary data related to this

  2022-06-18

  

  The following are the supplementary data related to this article. Transparency document Introduction Hypoxia is a pathological process that causes abnormal changes in metabolism, function and morphological structure of tissue because of insufficient oxygen supply. It's reported that hypoxia w

• br Acknowledgements This work was financially supported by t

  2022-06-18

  

  Acknowledgements This work was financially supported by the National Natural Science Foundation of China (Grant No. 81803033) and the “Double First-Class” University project (CPU2018GF02). Introduction Atrial fibrillation (AF) is the most common progressive cardiac rhythm disorder. Studies ha

• br Materials and methods br Results br

  2022-06-18

  

  Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data

• br Conclusion and perspectives Guanylyl cyclases are ubiquit

  2022-06-18

  

  Conclusion and perspectives Guanylyl cyclases are ubiquitous enzymes that regulate critical functions in bacteria to humans. In mammals there are seven mGCs and activators of all members have now been identified. Mutations in the genes that encode mGCs or pathologic activation of these enzymes or

• TUG 891 As a result of the capability of modulating

  2022-06-18

  

  As a result of the capability of modulating the dynamic changes and rearrangement of cytoskeletons, the Rho GTPases, in which RhoA, Cdc42 and Rac1 are best-characterized, have been highlighted as significant contributors for orchestrating neuronal development (Duman et al., 2015, Heasman and Ridley,

• SAG The PI K PTEN Akt

  2022-06-18

  

  The PI3K/PTEN/Akt/mTORC1/GSK-3 pathway also plays key roles in metabolism, obesity, diabetes and cardiovascular diseases (, , , , ). Sometimes such clinical problems such as diabetes, obesity and metabolic disorders are interlinked with cancer. Clearly further elucidation of the roles of GSK-3 could

• It was noted elsewhere that

  2022-06-17

  

  It was noted elsewhere that several of the variants (i.e., Indel19 and SNP63) that make up the risk haplotypes had unusually large differences in allele frequencies between Africans and non-Africans, as compared with a set of likely neutral loci (Fullerton et al. 2002). This finding was interpreted

• br Materials and methods br

  2022-06-17

  

  Materials and methods Results Discussion To the best of our knowledge, the current study presented the first evidence that GPR40, also named FFAR1, played an essential role in bone formation and mediated pdk 1 induced osteogenic effect via Wnt/β-catenin signaling. We found that dose–respons

• br Introduction The alternative splicing of pre mRNA

  2022-06-17

  

  Introduction The alternative splicing of pre-mRNA is essential for generating multiple matured mRNAs from a single gene by selectively removing introns. Neural melatonin receptor agonist show many examples of regulated alternative splicing events, which produce structural changes in proteins imp

• Analysis of genomic neighborhoods has

  2022-06-17

  

  Analysis of genomic neighborhoods has helped resolve questions concerning the orthology of receptors for peptides similar to glucagon (Ng et al., 2010, Irwin and Prentice, 2011, Wang et al., 2012, Hwang et al., 2013). Using a diverse array of species with available genome sequence (see Fig. 4) the g

• Ghsr may have therapeutic value in disorders associated

  2022-06-17

  

  Ghsr may have therapeutic value in disorders associated with impairments in AHN. As anxiety disorders and enhanced fear responses observed in PTSD are linked with overgeneralization of similar but distinct memories (i.e poor discrimination), we suggest that acyl-ghrelin’s anti-anxiety effect (Lutter

• Some aspects of intercellular Ca wave

  2022-06-17

  

  Some aspects of intercellular Ca2+ wave spread are similar to the phenomenon of spreading depression and associated with migraine headache [57]. These depolarization waves, followed by electrical inhibition, are evoked by transient hypoxia and other types of glycine transporter injury and spread sl

• r78 br FXR FGF in the control of

  2022-06-17

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, r78 and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membrane, newly-synthesized BA

• The regulatory effects of NADPH oxidase on ferroptosis

  2022-06-17

  

  The regulatory effects of NADPH oxidase on ferroptosis might also relate to neuroinflammation. Although ferroptosis can trigger inflammatory responses in the brain, neuroinflammation, in turn, can also modify ferroptosis. It has been reported that inflammatory conditions such as those found in neuro

• When taken together data suggest CRF plays a

  2022-06-17

  

  When taken together, data suggest CRF plays a central role in linking the HPA axis, the eCB system, and the amygdala with anxiety (Hill et al., 2009, 2010a; Hillard et al., 2011). In elaborate studies in mice, Gray and colleagues (Gray et al., 2015) showed stress-associated increase in CRF concentra

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