• With centralisation timely and efficient distribution networ

  2019-06-14

  

  With centralisation, timely and efficient distribution networks are key. However, mature blood distribution networks are yet to be established in most developing countries. For example, blood donated in Malawi\'s capital Lilongwe is sent to Blantyre (360 km away) for testing at MBTS before it is tra

• IL IL is another potential inhibitor

  2019-06-14

  

  IL-7: IL-7 is another potential inhibitor of OBL differentiation in MM that induces RANKL production by T lymphocytes [113] and mediates MM-induced OBL inhibition by down-regulating RUNX2 transcriptional activity [93]. IL-7 levels are increased in the marrow of MM patients and that IL-7 inhibited bo

• p53 tumor suppressor Lead failures are classified as either

  2019-06-14

  

  Lead failures are classified as either structural lead failures or electrical lead failures, and failures of 8F single coil leads are more frequently reported. Structural failures occur with a reported incidence of 14–34% and are evident as cable exteriorization in fluoroscopy studies [6,7]. Electri

• br Discussion Early repolarization is a common

  2019-06-14

  

  Discussion Early repolarization is a common ECG characteristic. Its reported prevalence is 6–25% of the general population, and is particularly common in athletes [2,3,11,12]. It is now recognized that a small fraction of people with early repolarization on their ECGs develop lethal tachyarrhythm

• Brugada syndrome BS is a hereditary arrhythmogenic disease

  2019-06-14

  

  Brugada syndrome (BS) is a hereditary arrhythmogenic disease characterized by a coved- or saddleback-type ST elevation in the right precordial lead on a 12-lead electrocardiogram (ECG) and ventricular fibrillation (VF) occurring mainly at night. During the past 2 decades, since Brugada and Brugada

• br Discussion Prehabilitation is a program to enhance

  2019-06-14

  

  Discussion “Prehabilitation” is a program to enhance functional capacity and psychological health to enable patients to withstand an upcoming stressor, e.g. surgery. It is intended to reduce treatment-related morbidity and/or mortality, to decrease length of hospital stay and/or re-admission, and

• br Over the past decade global

  2019-06-14

  

  Over the past decade, global concern about the disproportionate burden of disease and mortality in low-income countries, especially in sub-Saharan Africa, has led to a substantial influx of funding for research by many donor and research agencies. This investment has energised in-country research;

• With the publication of this month

  2019-06-14

  

  With the publication of this month\'s issue, we mark \'s first birthday. I hope you will allow me to effuse for a moment in the manner of a new parent discovering the fascination of her offspring\'s everyday achievements… Since its conception in March, 2013, the infant has maintained a healthy inta

• La Proclama se alaba que las Fuerzas armadas asum an

  2019-06-14

  

  La “Proclama” señalaba que las Fuerzas armadas asumían la conducción del Estado con el propósito de “terminar con el desgobierno, la corrupción y el flagelo subversivo.” En Guatemala, el “Comunicado Urgente al Pueblo” inmediatamente después del golpe del 23 de marzo de 1982 decía que: “El ejército

• Data on chloroquine resistance from

  2019-06-13

  

  Data on chloroquine resistance from Pakistan is scarce, even in the most recent global analysis. Nevertheless, in 2013, the emergence of the F1076L mutant of the gene—the auda responsible for chloroquine resistance—in in Pakistan highlights the imminent threat of resistant . In 2015, the first ca

• In the s several hospital based surveys were reported In

  2019-06-13

  

  In the 1990s, several hospital-based surveys were reported. In a survey of AF among 2686 acute medical admissions to a district general hospital in Glasgow, UK [4], the prevalence of AF was 6.3%, with the predominant associated medical conditions being ischemic heart disease, hypertension, and valvu

• br Discussion Clinically HES may be separated into

  2019-06-13

  

  Discussion Clinically, HES may be separated into two subgroups: HES with, and HES without gene abnormality such as PDGFRA, PDGFRB, or FGFR1. The standard therapy of HES without gene abnormality is steroid; by contrast, the first-line therapy of HES with gene abnormality is imatinib. Although in-

• dgat1 inhibitor We are aware that physician surveys

  2019-06-13

  

  We are aware that physician surveys have been previously used to assess; bisphosphonate use for bone pain [14], bisphosphonate use in metastatic breast cancer patients [15] and radiotherapy use for painful bone metastases [16] but are not aware of physician surveys being used to help design trials o

• In silico prediction software SIFT

  2019-06-13

  

  In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com

• br Drug resistant tuberculosis threatens to undermine advanc

  2019-06-13

  

  Drug-resistant tuberculosis threatens to undermine advances in tuberculosis control worldwide. Multidrug-resistant tuberculosis (MDRTB), defined as resistance to isoniazid and rifampicin, requires treatment for up to 24 months with expensive diagnostics and second-line drugs. Fewer than 15% of pat

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